Please check your email for instructions on resetting your password. J. Chem. Open Access Through ACS AuthorChoice High accumulation in the mitochondria was observed, contradicting prior fluorescence microscopy studies. DOI: 10.1021/acsmedchemlett.8b00580, Bioisosteres of Indomethacin as Inhibitors of Aldo-Keto Reductase 1C3 Electron. Through additional biochemical and chemical studies, we revealed that metal chelation likely plays a principle role in their mechanism of inhibition. Chem. ACS Appl. Published as part of a Crystal Growth and Design virtual special issue on Crystalline Functional Materials in Honor of Professor Xin-Tao Wu Hits, representatives of three chemical classes, were identified as inhibitors of CDK5. Mater. All Publications/Website. Chem., 2019, 91 (7), pp 4331–4336 DOI: 10.1021/acs.analchem.9b00169, Copper Ion Fluorescent Probe Based on Zr-MOFs Composite Material Environ. The structure provides key insight on the mechanism of inhibition as well as selectivity toward homologous enzymes and allows detailed mapping of the internal cavity of the enzyme that accommodates peptide-substrates. Eng., 2019, 7 (7), pp 6458–6470 Growth Des., 2019, 19 (4), pp 2476–2484 Further fine control over the kinetics has been achieved by changing the substitutions on the aniline ring: generally the substitution of aniline with strong electron withdrawing groups reduces the Type II character of these compounds. Chem. J. Phys. These studies conclusively show that 1 is capable of inhibiting tumor growth, providing further credibility for the use of these compounds as anticancer agents. Res., 2019, 58 (13), pp 5087–5087 Mol. The synthesized FAQ–pyrimidines displayed better in vitro potency than chloroquine (CQ) against the resistant P. falciparum strain (Dd2), exhibiting up to 47.3-fold better activity (IC50: 4.69 nM) than CQ (IC50: 222 nM) and 2.8-fold better potency than artesunate (IC50: 13.0 nM). Sci. Please reconnect. Energy Mater., 2019, 2 (4), pp 2358–2363 ACS Med. Mechanistic heme-binding studies, computational docking studies against Pf-DHFR and in vitro microsomal stability studies were performed for the representative molecules of the series to assess their antimalarial efficacy. Data, 2019, 64 (4), pp 1662–1670 DOI: 10.1021/acsinfecdis.8b00315, Multi-Omics Strategies Uncover Host–Pathogen Interactions Cationic lipids are key components of siRNA-lipid nanoparticles (LNP), which may serve as potential therapeutic agents for various diseases. Lett., 2019, 10 (4), pp 499–503 Nonmembers wishing to purchase a copy may click here and purchase at the non-member price. Mater., 2019, 1 (4), pp 485–493 Sci. We report a potent cationic lipid, SST-02 ((3-hydroxylpropyl)dilinoleylamine), which possesses a simple chemical structure and is synthesized just in one step. This article is part of the Hans-Joachim Freund and Joachim Sauer Festschrift special issue. Bisbenzyloxy can induce ER stress, and the N-(2-hydroxyethyl)formamide structure can increase the ratio of LC3II/I and cytoplasmic vacuolization and facilitates paraptosis. Org. Open Access Through ACS AuthorChoice J. Chem. DOI: 10.1021/acs.jmedchem.8b01888, FragLites—Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. Fragment-based drug discovery (FBDD) is a well-established technology for lead compound generation in drug discovery. Open Access Through ACS AuthorChoice DOI: 10.1021/acsabm.8b00686, Achieving a Stable High Surface Excess of Glucose Oxidase on Pristine Multiwalled Carbon Nanotubes for Glucose Quantification Sci. Pharmaceutics, 2019, 16 (4), pp 1658–1668 Interestingly, although direct, albeit weak, binding to the pre-microRNA hairpins was observed, the inhibitory activity of these compounds was not due to RNA binding. DOI: 10.1021/acsaelm.9b00078, All-Liquid Electroactive Materials for High Energy Density Organic Flow Battery Atherosclerosis and its associated clinical complications are major health issues in industrialized countries. Sci. A, 2019, 123 (15), pp 3389–3394 DOI: 10.1021/acs.jafc.8b05147, Alterations of Bile Acids and Gut Microbiota in Obesity Induced by High Fat Diet in Rat Model Although some research activities are slowly resuming, many institutions remain closed, with researchers working from home under unusual circumstances. Inf. To obtain a new anticancer drug, we focused on FER tyrosine kinase. Cryst. Bio Mater., 2019, 2 (4), pp 1542–1548 Now more than ever, it is important to mention clearly which suggestions you consider to be essential. Energy Mater., 2019, 2 (4), pp 2708–2716 DOI: 10.1021/acs.oprd.8b00247, Development of a Synthetic Process for K-8986, an H1-Receptor Antagonist Chem. This Viewpoint highlights some of the differences between these two cultures and strategies to succeed in academic drug discovery. Noncatechol heterocycles have recently been discovered as potent and selective G protein biased dopamine 1 receptor (D1R) agonists with superior pharmacokinetic properties. DOI: 10.1021/acsenergylett.9b00500, High-Concentration Ether Electrolytes for Stable High-Voltage Lithium Metal Batteries ACS Comb. J. Phys. Twelve compounds exhibited better antiplasmodial activity than CQ against the CQ-sensitive (NF54) strain. DOI: 10.1021/acscombsci.8b00152, Biophysical Characterization Platform Informs Protein Scaffold Evolvability Our structure–activity optimization efforts have led to the discovery of BNC375, a small molecule with good CNS-drug like properties and clinical candidate potential. In contrast, analogue 7 showed the highly reduced IL-17 secretion, which may indicate potential anti-inflammatory effects. Interfaces, 2019, 11 (14), pp 13039–13057 J. Chem. In THP1 cells, GSK8612 was able to inhibit secretion of interferon beta (IFNβ) in response to dsDNA and cGAMP, the natural ligand for STING. Energy Fuels, 2019, 33 (4), pp 3162–3175 ACS Sustainable Chem. J. Proteome Res., 2019, 18 (4), pp 1503–1512 J. Agric. Data, 2019, 64 (4), pp 1826–1833 ACS Comb. DOI: 10.1021/acssuschemeng.9b00155, Biomass-Derived Renewable Carbonaceous Materials for Sustainable Chemical and Environmental Applications On the other hand, trying to automate unproven or difficult processes may seem to be risky but can actually accelerate the adoption, modification, or rejection of novel technologies. Open Access Through ACS AuthorChoice DOI: 10.1021/acs.iecr.9b01388, A General Framework for Process Synthesis, Integration, and Intensification He received the Swiss Industrial Science Prize in 2019 from the Swiss Chemical Society. About Organic Letters. DOI: 10.1021/acscombsci.8b00182, Dynamical Correlations for Statistical Copolymers from High-Throughput Broad-Band Dielectric Spectroscopy Environ. Lett., 2019, 10 (4), pp 437–443 Chem. This article is part of the Highlighting Medicinal Chemistry in Italy special issue. J. Chem. ACS Appl. Sci. J. Chem. DOI: 10.1021/acsaelm.8b00090, High-Mobility MoS2 Directly Grown on Polymer Substrate with Kinetics-Controlled Metal–Organic Chemical Vapor Deposition Interfaces, 2019, 11 (13), pp 12880–12889 Open Access Through ACS AuthorChoice The ability to obtain high-resolution crystal structures of ERAP1 removes a major bottleneck in the development of compounds that regulate its activity and will greatly accelerate drug-discovery efforts. 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