Brand Names: Not yet available. Sucralose is a general purpose sweetener that can be found in a variety of foods including baked goods, beverages, chewing gum, gelatins, and frozen dairy desserts. Are you experiencing a shortage of dextrose anhydrous? Aspartame brand names include Nutrasweet®, Equal®, and Sugar Twin®. It can be blended with many other natural and artificial sweeteners. High-intensity sweeteners are commonly used as sugar substitutes or sugar alternatives because they are many times sweeter than sugar but contribute only a few to no calories when added to foods. Advantame – AVOID. The most common examples of excipients used for the purpose of sweetening drug formulations are shown below. Before sharing sensitive information, make sure you're on a federal government site. In the case of the high-intensity sweeteners that are subjects of GRAS notices (i.e., certain high-purity steviol glycosides and SGFE), the notifiers did not include use in meat and poultry products as an intended condition of use in the GRAS notices that they submitted for FDA’s evaluation. Products containing saccharin no longer have to carry the warning label. The selection of candidate sweeteners is informed by technical, regulatory and clinical considerations. It is heat stable, meaning that it stays sweet even when used at high temperatures during baking, making it suitable as a sugar substitute in baked goods. People who have phenylketonuria (PKU), a rare genetic disorder, have a difficult time metabolizing phenylalanine, a component of both aspartame and advantame – a new artificial sweetener that is chemically related to aspartame. He has 15 years of experience in taste assessment and taste masking of investigational and approved drugs for children and adults, leveraging his background in sensory science and food chemistry. Because it is much sweeter than most low and non-calorie sweeteners currently available, it is anticipated to be a top candidate for food and beverage … However, people with a rare hereditary disease known as phenylketonuria (PKU) have a difficult time metabolizing phenylalanine, a component of aspartame, and should control their intake of phenylalanine from all sources, including aspartame. Sucralose is about 600 times sweeter than sugar. Supported by Roquette’s…. From a taste masking perspective, the sweetness profile – intensity, onset and duration – is critically important. In determining the safety of neotame, FDA reviewed data from more than 113 animal and human studies designed to identify possible toxic effects, including effects on the immune system, reproductive system, and nervous system. © 2020 - Pharma Excipients. Some excipients that are sweet are often incorrectly listed in publications as “sweeteners.” These are excipients used primarily for purposes other than imparting sweetness, for example, co-solvents such as glycerol or propylene glycol, and bulking agents such as lactose or maltodextrin. As of July 2000, ALL Pedialyte products, including flavored and freezer pops, contain the chemical sweetener acesulfame-K, plus artificial colors, and artificial flavors. Advantame is approved for use in food as a non-nutritive sweetener. Saccharin is approved for use in food as a non-nutritive sweetener. It is about 200 times sweeter than sugar and is often combined with other sweeteners. Some have been determined to be Generally Recognized as Safe (GRAS) by the manufacturer, or by the Flavor and Extract Manufacturers Association (FEMA) in accordance with the 1958 Food Additives Amendment to the Federal Food, Drug and Cosmetic Act. Interstingly, products containing only aspartame must bear an informational statement for people with PKU alerting them about the presence of phenylalanine. If FDA is notified under the GRAS Notification Program that a high-intensity sweetener is GRAS for use in a meat or poultry product, FDA would evaluate whether the notice provides a sufficient basis for a GRAS determination and whether information in the notice or otherwise available to FDA raises issues that lead the agency to question whether the use of the high-intensity sweetener is GRAS. Sucralose has been extensively studied and more than 110 safety studies were reviewed by FDA in approving the use of sucralose as a general purpose sweetener for food.